Drug Discovery Capabilities
in Vivo PHARMACOLOGY
Beacon's in vivo team is comprised primarily of behavioral pharmacologists with expert animal handling and testing skills working in a state-of-the-art small animal vivarium. The Beacon team:
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Works across therapeutic areas, although focus has been largely CNS and behavioral pharmacology
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worked on a diverse range of programs, both alone and in collaboration with industry partners, with several programs reaching clinical development
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Runs all rodent in vivo screening, POC characterization, CNS safety, and exploratory tox studies in-house
Assays developed/established in house sorted by therapeutic or functional area include (but not limited to):
in Vivo PHARMACOLOGY
Beacon's in vivo team is comprised primarily of behavioral pharmacologists with expert animal handling and testing skills working in a state-of-the-art small animal vivarium. The Beacon team:
-
Works across therapeutic areas, although focus has been largely CNS and behavioral pharmacology
-
worked on a diverse range of programs, both alone and in collaboration with industry partners, with several programs reaching clinical development
-
Runs all rodent in vivo screening, POC characterization, CNS safety, and exploratory tox studies in-house
Assays developed/established in house sorted by therapeutic or functional area include (but not limited to):
Gastrointestinal Disorders
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UC/Crohn's: Gut Barrier Function (NSAID Damage, FITC transport, DSS, TNBS)
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UC/Crohn's: Immune modulation (T Cell adoptive transfer)
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Liver Fibrosis (CCL4, Bile duct ligation, Bleomycin)
Metabolism
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Acute and chronic food intake monitoring
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Meal patterning (behavioral satiety sequence)
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Conditioned taste aversion
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Insulin tolerance test
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IP/IV/Oral glucose tolerance tests
Emotion/Anxiety/Depression
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Open field
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Startle/fear potentiated startle
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Ultrasonic vocalisations
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Defensive burying
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Tail suspension
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Marble Burying
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Plus Maze/O-Maze
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Geller-Seifter conflict
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DRL Schedules
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Schedule-induced polydipsia
Schizophrenia/Psychosis/antipsychotic-sensitive
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Prepulse inhibition
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Catalepsy: Raised bar, grid, hind-over-forelimb
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Conditioned avoidance responding
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Social Interaction
Pain and Pruritis
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Tail Flick (spinal)
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Paw plethysmometry, Formalin, carageenan & CFA (inflammatory)
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Paw Incision (surgical)
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Pruritis
Seizure
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PTZ-threshold
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Maximum Electroshock (MES
Oncology
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CDX and PDX rodent models
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Carcinogen Induced Cancers
Basic neurological function
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Modified Irwin test: General observations, tail flick, grip strength, body temperature, motor activity, catalepsy, reflexes, coordination
Motor control/parkinsons
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6-OHDA lesions (rotation)
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Gait Assessment
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Carcinogen Induced Cancers
Anhedonia/reward/motivation
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Conditioned place preference
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Locomotor activity, sensitisation
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Operant work, Drug discrimination; Sucrose preference; Progressive ratio
Cognitive function
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(Object recognition)
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Fear conditioning
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Social communication of a food preference
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Operant work:
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Delayed (non) match to sample?
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DNMTP (standard and TUNL)
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5-choice serial reaction time task
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Continuous Performance Task (CPT)
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Serial order task
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Reveral learning
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Domain
- Recognition memory/visual discrimination
- Associative learning
- Working memory
- Working memory
- Attention
- Attention
- Episodic working memory?
- Visual discrimination/cognitive flexibility
Miscellaneous
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Radiotelemetry (EEG, CV)
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Sleep patterning
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Neuroendocrine profiling
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H3 agonist-induced polydipsia
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Kappa agonist-induced diuresis
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Neuroendocrine profiling
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IEG Mapping
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C13 dietary profiling